Intrahepatic expression of interferon alpha & interferon alpha receptor m-RNA can be used as predictors to interferon response in HCV and HCC patients
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چکیده
منابع مشابه
Correlation Between Interferon Alpha Receptor Protein Expression and Sensitivity to Interferon Alpha Subtypes in Human Renal Carcinoma Cell Lines
1109-6535/2004 $2.00+.40 Abstract. Background: We have previously characterized the antitumor activities and immunological properties of interferon-alpha (IFN-·) subtypes on renal cell carcinoma (RCC). However, the mechanism responsible for the different biologic activities among the IFN-· subtypes is still unclear. To explain the different cellular sensitivities to IFN-· subtypes, detailed exp...
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Corresponding Author: Naglaa F. Alhusseini Department of Medical Biochemistry, Faculty of Medicine, Benha University, Egypt Email: [email protected] Abstract: Hepatitis C Virus (HCV) infection is one of the main causes of chronic liver disease worldwide. Egypt has the highest prevalence of Hepatitis C Virus (HCV) in the world, estimated nationally at 14.7%. knowledge of the predic...
متن کاملEffectiveness of leukocyte interferon in patients affected by HCV-positive mixed cryoglobulinemia resistant to recombinant alpha-interferon.
OBJECTIVE Interferon is the first-choice therapy for HCV-positive mixed cryoglobulinemia, but only a small fraction of the patients show long-term recovery from the disease. In non-responders or relapsers, the second-line therapy (high dose interferon) generally is not effective. The aim of this study was to evaluate the effectiveness of leukocyte interferon as a second-line therapy in patients...
متن کاملRole of interferon anti body in predicting the response to interferon therapy in HCV patients.
OBJECTIVE To see the frequency of formation of interferon antibodies in patients receiving alpha interferon and evaluate their role in treatment response. METHODS Patients with chronic Hepatitis C receiving alpha interferon three times a week along with daily ribavarin in two gastroeneterolgy departments of public hospitals, running hepatology clinics were studied. Blood for interferon antibo...
متن کاملEFFICACY AND SAFETY OF COMBINATION THERAPY OF INTERFERON-ALPHA 2B PLUS RIBAVIRIN FOR CHRONIC HEPATITIS C
Introduction: The aim of this study is to assess the therapeutic efficacy and safety of a particular brand of IFN alpha (PDferon B®) in combination with ribavirin (RlBA) on Iranian patients with chronic hepatitis C (CHC). The addition of RIBA to the standard treatment with interferon (IFN) alpha led to an improvement in sustained virologic response (SVR) from less than 20% with IFN monother...
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ژورنال
عنوان ژورنال: African Journal of Health Sciences
سال: 2008
ISSN: 1022-9272
DOI: 10.4314/ajhs.v14i1.30851